GREEN TEA EXTRACT (EGCG) and CANCER - New research on Epigallocatechin 3-gallate - 4 papers reviewed - big pharma is rushing human Clinical Trials. Why?

Papers reviewed:

• 2023 July, Kciuk et al - Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

• 2022 Ferrari et al - The Potential of Epigallocatechin Gallate (EGCG) in Targeting Autophagy for Cancer Treatment: A Narrative Review

• 2022 Alam et al - Epigallocatechin 3-gallate: From green tea to cancer therapeutics

• 2024 Mar, Talib et al - Targeting Cancer Hallmarks with Epigallocatechin Gallate (EGCG): Mechanistic Basis and Therapeutic Targets

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2023 July, Kciuk et al - Epigallocatechin-3-Gallate Therapeutic Potential in Cancer: Mechanism of Action and Clinical Implications

• Majority of green tea’s positive effects on human health can be attributed to the high polyphenol and flavonoid content.

• Catechins, which are the primary flavonoids found in green tea, account for about 30–40% of the solid components of this plant (EGCG is one of them).

• Epigallocatechin-3-gallate (EGCG) = most abundant phenolic compound in green tea

• EGCG has gained scientific interest due to its antioxidant, anti-inflammatory, anti-fibrotic, and anti-cancer properties

• One cup of Green Tea (250mL) contains ~ 177mg EGCG

Anti-Cancer Mechanisms